Effect of Curcumin on Interleukin-6 Expression and Malondialdehyde Levels in Liver Fibrosis

BACKGROUND: Chronic inflammation and excessive oxidative stress are the main mechanisms causing liver fibrosis. It releases anti-inflammatory cytokines, namely, interleukin 6 (IL-6), nitric oxide, malondialdehyde (MDA). Curcumin acts as an anti-inflammatory, antioxidant, antifibrotic. AIM: This study is aimed to analyze differences in IL-6 expression MDA levels (Deutschland, Denken, Yoken) DDY mice with fibrosis after common bile duct ligation between curcumin-treated control groups. METHODS: research experimental a post-test-only group design. Seventy-five male 20–30g were used this (n = 5). Mice randomly divided into five groups, each consisting of 15 mice. The first healthy (HC) was HC given phosphate-buffered saline (PBS) solution did not perform CBDL. second negative (NC) NC PBS completed third positive (PC) PC oral ursodeoxycholic acid (UDCA) performed fourth (P1) assigned curcumin fifth (P2) UDCA Seven, fourteen, 21 days ligation, samples taken examine levels. RESULTS: There significant difference groups (p 0.00), P1 P2 0.04), on day 0.00). Statistical analysis comparison 7 14 found no difference. On 21, there substantial 0.02). CONCLUSION: concluded that effectively reduced